02446: Development of Genetic Biomarkers to Improve Diagnosis and Treatment of Canine Histiocytic Sarcoma

Grant Status: Closed

Grant Amount: $138,107
Benoit Hédan, DVM, PhD; CNRS - University of Rennes
May 1, 2018 - October 31, 2021

Sponsor(s): Bernese Mountain Dog Club of America, Rottweiler Health Foundation

Breed(s): Flat-Coated Retriever, Bernese Mountain Dog, Rottweiler
Research Program Area: Oncology
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Abstract

Several breeds of dog, including Retrievers, Bernese Mountain Dogs and Rottweilers, are known to present elevated risks of cancers including histiocytic sarcoma (HS), lymphoma, and hemangiosarcoma. HS may be misdiagnosed due to clinical presentation shared with these other cancers. Due to the aggressiveness of HS and its late diagnosis, there is no known effective treatment. With different prognostic and therapeutic options, an early and accurate diagnosis of cancer is important to select appropriate therapies to improve outcomes for affected dogs, while still being cost effective. There is a need for the development of biomarkers for early and precise detection of such cancers. The research team has identified tumoral DNA alterations specific to HS and will use these unique alterations to improve early diagnosis of HS and to develop more specific therapies. Moreover, the investigators have been able to detect these biomarkers, already used in their lab to discriminate HS, in the blood of affected dogs. The objectives of this study are to develop a non-invasive diagnostic blood test using genetic biomarkers to accurately diagnose HS, and to explore earlier diagnosis to improve treatment outcomes through the selection of targeted therapies.

Publication(s)

Hédan, B., Cadieu, É., Rimbault, M., Vaysse, A., Citres, C. D. de, Devauchelle, P., Botherel, N., Abadie, J., Quignon, P., Derrien, T., & André, C. (2021). Identification of common predisposing loci to hematopoietic cancers in four dog breeds. PLOS Genetics, 17(4), e1009395. https://doi.org/10.1371/journal.pgen.1009395

Prouteau, A., Denis, J. A., De Fornel, P., Cadieu, E., Derrien, T., Kergal, C., Botherel, N., Ulvé, R., Rault, M., Bouzidi, A., François, R., Dorso, L., Lespagnol, A., Devauchelle, P., Abadie, J., André, C., & Hédan, B. (2021). Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma. Scientific Reports, 11(1), 877. https://doi.org/10.1038/s41598-020-80332-y

Hédan, B., Rault, M., Abadie, J., Ulvé, R., Botherel, N., Devauchelle, P., Copie‐Bergman, C., Cadieu, E., Parrens, M., Alten, J., Zalcman, E. L., Cario, G., Damaj, G., Mokhtari, K., Loarer, F. L., Coulomb‐Lhermine, A., Derrien, T., Hitte, C., Bachelot, L., … André, C. (2020). PTPN11 mutations in canine and human disseminated histiocytic sarcoma. International Journal of Cancer. https://doi.org/10.1002/ijc.32991

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