0001729: Canine Epilepsy: Determining the Mode of Inheritance, Mapping the Genes, and Developing Linkage Test

Grant Status: Closed

Grant Amount: $57,500
James R. Mickelson, PhD; University of Minnesota
March 23, 1999 - March 22, 2001

Sponsor(s): English Springer Spaniel Field Trial Association Foundation, National Beagle Club, Vizsla Club of America Welfare Foundation

Breed(s): Beagle, Standard Schnauzer, Vizsla
Research Program Area: Neurology
Donate to Support this Research Program Area

Project Summary

This project determined the mode of inheritance for epilepsy in three breeds. For Vizslas, the researchers found that epilepsy is most likely an autosomal recessive trait (each parent must pass on one of the genes in order for puppies to be affected); for English Springer Spaniels, epilepsy is consistent with either simple autosomal recessive (carried on one gene) or polygenic recessive. For Beagles, it appears that epilepsy may be a sex-influenced recessive trait. In addition, the researchers began scanning the genome to look for linkages suggestive of epilepsy in all three breeds. This initial project has set the stage for identifying the epilepsy genes in those breeds. The groundwork accomplished allows a further, ongoing study to continue as the researchers work toward the goal of developing a genetic test so that breeders can make breeding decisions to eliminate the disease. The work done in these three breeds should provide assistance for researchers working on epilepsy in other breeds as well.


Patterson, E. E., Armstrong, P. J., O’Brien, D. P., Roberts, M. C., Johnson, G. S., & Mickelson, J. R. (2005). Clinical description and mode of inheritance of idiopathic epilepsy in English Springer Spaniels. Journal of the American Veterinary Medical Association, 226(1), 54–58. https://doi.org/10.2460/javma.2005.226.54

Patterson, E. E., Mickelson, J. R., Da, Y., Roberts, M. C., McVey, A. S., O’Brien, D. P., … Armstrong, P. J. (2003). Clinical Characteristics and Inheritance of Idiopathic Epilepsy in Vizslas. Journal of Veterinary Internal Medicine, 17, 319–325.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Connect With Us:
Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617

Tax ID# 13-3813813

   2020 GuideStar logo

© 2020 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software