1614: Development of a DNA-Based Diagnostic Test for Craniomandibular Osteopathy of the Cairn Terrier, West Highland White Terrier, and Scottish Terrier Breeds
Grant Status: Closed
Grant Amount: $60,000
Patrick Venta, PhD; Michigan State University
September 25, 1998 - September 24, 2000
Sponsor(s): Scottish Terrier Club of America, The Foundation of the Cairn Terrier Club of America, Westie Foundation of America, Inc.
Breed(s): West Highland White Terrier, Cairn Terrier, Scottish Terrier
Research Program Area: Musculoskeletal Conditions and Disease
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Project Summary
This project found that the canine version of two candidate genes known to be responsible for similar diseases in humans do not appear to be responsible for Craniomandibular Osteopathy (CMO) in Terriers. CMO is a painful, non-cancerous proliferation of the bone, primarily around the jaw, that lasts for a year, starting at the age of six weeks to six months. After ruling out the candidate genes, researchers started to scan the entire canine genome, looking for the causative gene for the disease. So far they have examined about 30 percent of the genome and have yet to find the gene, though the research continues. As part of this study, researchers discovered an improved approach to whole genome scans that will benefit all genetic researchers.Publication(s)
Brouillette, J. A., & Venta, P. J. (2002). Within-breed heterozygosity of canine single nucleotide polymorphisms identified by across-breed comparison. Animal Genetics, 33(6), 464–467. https://doi.org/10.1046/j.1365-2052.2002.00918.x
Housley, D. J. E., Ritzert, E., & Venta, P. J. (2004). Comparative radiation hybrid map of canine chromosome 1 incorporating SNP and indel polymorphisms. Genomics, 84(2), 248–264. https://doi.org/10.1016/j.ygeno.2004.04.001
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