1608B: Integrated Map of Canine Gene and Microsatellite Loci
Grant Status: Closed
Grant Amount: $100,000
Elaine A Ostrander, PhD; Fred Hutchinson Cancer Research Center
July 20, 1998 - July 19, 2000
Sponsor(s): Nestle Purina PetCare Company
Breed(s): -All Dogs
Research Program Area: General Canine Health
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Project Summary
In this collaborative project, experienced laboratories worked together to produce an integrated physical and genetic map of the canine genome. The linkage map, which plots genetic markers (repeated sequences of DNA code), was combined with an expanded radiation hybrid (RH), or physical, map to create an integrated map with 774 markers that included 220 genes. This resulted in a well-ordered map of the canine genome that linked it to the much more well-developed human map of genes and markers. This important project produced an easily usable map, available to all, and serves as an important resource to researchers who are interested in mapping disease genes in the dog.Publication(s)
Breen, M. (2001). Chromosome-Specific Single-Locus FISH Probes Allow Anchorage of an 1800-Marker Integrated Radiation-Hybrid/Linkage Map of the Domestic Dog Genome to All Chromosomes. Genome Research, 11(10), 1784–1795. https://doi.org/10.1101/gr.189401
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
