Identifying Early Stage Ultra-rare Mutations as Predictive Biomarkers of Lymphoma in High-risk versus Low-risk Breeds Within the Dog Aging Project

02/25/2020
Breed(s): Greyhound, Rottweiler, Labrador Retriever, Boxer, Chow Chow, Dalmatian
Sample Type: Blood Sample
Study Location: University of Washington
CHF-funded Grant: 02772

The most common type of cancer in dogs is lymphoma, with ~80,000 cases diagnosed annually in the US. Breeds vary considerably in their risk of lymphoma, but it is unclear what accounts for this variation. Cancer typically arises from the accumulation of non-inherited (i.e., somatic) mutations. The purpose of this study is to test the hypothesis that breeds at high risk of lymphoma have higher frequencies of precancerous somatic mutations in white blood cells. This study uses a new technology that makes it possible to detect extremely rare mutations in very small samples of blood with high accuracy. This method represents a >10,000-fold improvement in accuracy over previous methods, and so makes our study possible. By determining if mutation frequency in blood of healthy high-risk and low-risk companion dogs can predict lymphoma risk, this work could lead to the development of novel tests for the early diagnosis and prognosis of canine lymphoma.

The study seeks healthy dogs free of any cancer, with the goal of better understanding canine lymphoma.

Participation Requirements:

Six breeds are included: Boxers, Chow Chows, Dalmatians, Greyhounds, Labrador Retrievers, Rottweilers

Healthy dogs of any age and sex
Willingness to provide blood sample from dog at veterinary clinic

Owner's Responsibilities:

Owners will be asked to bring their dog to a veterinary clinic for the purpose of collecting a blood sample. The sample will be picked up in clinic by a lab technician from the University of Washington immediately following the blood draw.
Owners will be asked to provide an electronic medical record from their veterinarian to confirm the current health status of the dog.

Geographic Location:

  • Dog living in King County, Washington.
  • Dog can present to any clinic willing to participate.
  • Samples could be sent from other clinics if PBMCs are first isolated and frozen.

More Information

 

Contact Information:

Name: Daniel Promislow
Email: promislo@uw.edu
Phone: 206 616-6994

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Connect With Us:
Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617
(888)-682-9696

Tax ID# 13-3813813

   2020 GuideStar logo

© 2020 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software