Identification of genetic risk allele(s) associated with the development of tricuspid valve dysplasia in the Labrador Retriever
Tricuspid valve dysplasia is an inherited heart defect that is characterized by an abnormally formed tricuspid valve on the right side of the heart. It is reported to be most commonly observed in the Labrador Retriever although it has been observed in a few other breeds as well including the Boxer and Golden Retriever among others. Although some affected dogs only have a very mild valve malformation and can live quite comfortably with the defect, others are born with a very abnormal valve that results in heart valve leakage and the eventual development of congestive heart failure. Tricuspid valve dysplasia has been shown to be an inheritable trait in the Labrador Retriever and has been suggested to be a single gene defect. Here, we propose to identify a genetic marker for tricuspid valve dysplasia in the Labrador Retriever and to use this information to develop a strategy to gradually reduce the prevalence of the variant and tricuspid valve dysplasia in the Labrador Retriever.
Additional Information:
We ask that the following information is submitted with each sample:
• Name of dog
• Age
• Owner name
• Owner address
If possible, please provide the following with your sample submission:
• Pedigree
• Echocardiogram/cardiology reports
• Any relevant clinical or familial history
Shipping information:
NCSU—College of Veterinary Medicine
ATTN: Veterinary Cardiac Genetics Laboratory
RB 336
1060 William Moore Dr
Raleigh, NC 27607
Samples can be shipped at room temperature. While overnight shipping is not required, prepaid overnight shipping labels can be provided via email request.
Name: Kerry O’Donnell
Email: cvm-cardiacgenetics@ncsu.edu
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