Identification of Genetic Markers for Subvalvular Aortic Stenosis in Bullmastiffs

dc 4/26/2018

Subvalvular aortic stenosis (SAS) is one of the most common diagnosed heart defects in dogs and the Bullmastiff breed is over-represented in incidence of SAS. Mildly affected dogs may have a normal lifespan, but moderate or severely affected dogs are at risk for developing cardiac complications. There is currently no surgical or pharmacological intervention available that can significantly increase the lifespan of affected Bullmastiffs. The aim of this study is to identify genes/variants associated with SAS in Bullmastiff that can be used to develop a genetic test for this condition. 
  
To participate in this study we will need the following items:    
1.    Submission of 2-3ml of whole blood in a purple top EDTA tube.
2.    A copy of the 3-generation pedigree (if available)
3.    A copy of the echocardiogram report from a board certified cardiologist
4.    Completed enrollment form

To receive a copy of the enrollment form and if you have questions regarding sample submission or the study please email esontiveros@ucdavis.edu. 

Download the sample submission form!

Read more about AKC CHF grant #2327-MOU here.