Evaluation of a Potential Therapy for Canine Degenerative Myelopathy

Breed(s): Pembroke Welsh Corgi, Bernese Mountain Dog, Rhodesian Ridgeback, Chesapeake Bay Retriever, German Shepherd Dog, Boxer
Sample Type: Clinical Study
Study Location: University of Missouri
CHF-funded Grant: 02165-MOU

The purpose of this study is to evaluate a promising new drug as a treatment for DM with hopes to slow disease progression.  Dogs will be administered an antisense oligonucleotide (ASO) that will partially silence the production of the protein, superoxide dismutase 1 (SOD1).  The ASO has been tested in a preclinical setting for safety in dogs.  The drug will be injected into the spinal fluid at the low lumbar region of the spinal cord.  The study will be randomized and double-blinded; neither the investigator nor the pet owner will know whether the dog receives the drug. Eight dogs will receive the drug and four dogs will receive the vehicle. Based on the randomization design, each dog has a 67 percent chance of receiving the therapy.  Specific inclusion criteria include early disease stage, relative good health, no significant findings on spinal cord MRI, homozygosity for the SOD1 mutation and study compliance.

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More Information


Contact Information:

Name: Joan Coates
Email: coatesj@missouri.edu
Phone: 573-882-7821

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