Clinical and Molecular Genetic Analysis of Juvenile-Onset Laryngeal Paralysis in American Staffordshire Terriers

Breed(s): American Staffordshire Terrier
Sample Type: DNA Sample
Study Location: University of Missouri
CHF-funded Grant: 02535-MOU

We will attempt to identify the molecular genetic cause of a newly recognized, fatal, neurologic disease referred to as American Staffordshire Terrier juvenile laryngeal paralysis and polyneuropathy (AST-JLPP) by generating and analyzing whole genome sequences with DNA from affected puppies with AST-JLPP. A genome-wide association study will be used to map the AST-JLPP. Successful discovery of the causal mutation would provide a basis for DNA tests that could be used to confirm a diagnosis of AST-JLPP and aid breeders for marker-based breeding strategies. 

Participation Requirements:

Affected puppies diagnosed with AST-JLPP

Owner Responsibilities (Samples to be collected):

DNA samples (via whole blood in EDTA, OR, buccal cells on FTA-elute cards)

Pedigree copy (if available)

More Information


Contact Information:

Name: Dr. Gary Johnson; Liz Hansen (for participation)


Phone: 573-884-3712

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