Susceptibility Testing Aids Treatment of Granulomatous Colitis
CHF Grant 02050: Defining the Genetic Susceptibility to Granulomatous Colitis, a Severe Form of Inflammatory Bowel Disease
CHF Grant 1445: Granulomatous Colitis In Boxer Dogs: Genetic Analysis of Disease and Functional Analysis of Bacterial Killing
Publication: Manchester, A. C., Dogan, B., Guo, Y., & Simpson, K. W. (2020). Escherichia coli-associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15995
What can we learn?
Investigators analyzed clinical outcomes from cases of granulomatous colitis (a severe form of IBD seen in Boxers and French Bulldogs) to determine if susceptibility testing improved clinical outcomes and to evaluate E. coli antibiotic resistance. More than 80% of cases that were treated based on susceptibility testing had a positive long-term response. Fluoroquinolone resistance was common in the E. coli strains cultured, but it was not clonal.
Definitive diagnosis with intestinal biopsy and culture and susceptibility testing is strongly recommended before treating colitis with prolonged courses of broad-spectrum antibiotics such as fluoroquinolones.
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