Displaying results 21 - 30 of 31 items found.
(File; Mon Nov 15 19:22:00 CST 2010)
Description: Summaries of the presentations made at the 2005 National Parent Club Canine Health Conference.
(File; Tue Nov 16 07:43:00 CST 2010)
Description: Summaries of the presentions made at the 2002 Dog Owners and Breeders Symposium at the University of Florida College of Veterinary Medicine.
(File; Fri Nov 12 09:59:00 CST 2010)
Description: Presenation summaries from the 2005 Tufts Canine and Feline Breeding and Genetics Conference.
(Web Page; Fri Apr 13 09:54:00 CDT 2018)
Background: Canine Addison's disease is a dog's inability to produce one or two hormones due to a deficiency of corticosteriods and mineralocorticoids produced by the adrenal glands. In Nova Scotia Duck Tolling Retrievers (NSDTRs) this disorder is much more common than in the general dog population and is inherited. While genetic studies of NSDTRs with Addison's disease have excluded many candidate genes, researchers are still in search of the causative mutations. Objective: This study is extensively examining the entire canine genome utilizing state-of-the-art technologies in search of areas that are associated with this disease in NSDTRs.
(File; Thu Oct 28 10:17:00 CDT 2010)
Description: The AKC Canine Health Foundation 2007 Annual Report contains audited financials for 2006 and 2007 and the Foundation's accomplishments for the year 2007.
(File; Thu Oct 28 12:16:00 CDT 2010)
Description: The AKC Canine Health Foundation 2008 Annual Report contains audited financials for 2007 and 2008 and the Foundation's accomplishments for the year 2008.
(File; Thu Oct 28 09:24:00 CDT 2010)
Description: The AKC Canine Health Foundation 2000 Annual Report contains audited financials for 1999 and 2000 and the Foundation's accomplishments for the year 2000.
(Web Page; Fri Apr 13 08:35:00 CDT 2018)
Background: Canine Addison's disease is a late onset disorder caused by deterioration of the adrenal gland cortex and insufficient production of glucocorticoids and mineralocorticoids normally produced by that tissue. These hormones are involved in pathways important to normal body function including energy production, blood pressure, and stress response. Treatment is available but is expensive and life-long. Furthermore, delay in diagnosis and treatment can be fatal. Although hypoadrenocorticism occurs in the general canine population, some breeds show a greater prevalence particularly the Bearded Collie. We have demonstrated that hypoadrenocorticism is highly heritable in this breed and likely reflects the presence of a very small number of susceptibility genes. Objective: The researchers are using the canine single nucleotide polymorphism (SNP) test to perform an extensive genome scan of the DNA from Bearded Collies with the goal of identifying genomic regions associated with hypoadrenocorticism. Identifying probable locations that harbor mutations will allow the characterization of the gene(s) that cause this disease.
(Web Page; Tue Apr 23 09:12:00 CDT 2019)
Background: Autoimmune disorders, for which hypothyroidism is one, have been cited by dog breeders as a concern. Reports suggest that higher inbreeding is correlated with autoimmune disease expression. A diagnosis of hypothyroidism often accompanies other immune mediated diseases and many breeds are afflicted with several autoimmune disorders. This evidence suggests different autoimmune diseases actually reflect a common set of susceptibility genes that express differentially depending upon additional genetic mutations carried by an individual dog. Objective: The researchers are extensively examining the entire canine genome utilizing state-of-the-art technologies to search for chromosomal regions associated with hypothyroidism. They will then explore the genetic relationship between hypothyroidism and another immune mediated disease present in the Bearded Collie population, Addison's disease. Common genomic regions associated with both diseases would suggest a single set of susceptibility genes underlying endocrine immune mediated disorders.
(Web Page; Tue Jan 09 13:49:00 CST 2018)
Description: In 1997 the Soft-coated Wheaten Terrier (SCWT) Club of America helped us start an Open Registry which lists dogs affected with familial diseases common to this breed such as inflammatory bowel disease (IBD), protein-losing enteropathy (PLE), protein-losing nephropathy (PLN), combination PLE/PLN, Addison's disease (AD), and juvenile renal disease/renal dysplasia (JRD). The 2009 update lists almost 1000 affected dogs, with the vast majority affected with PLN, PLE, or PLE/PLN, in that order. These protein-losing diseases have had a devastating impact on the SCWT breed because: 1) there are no predictive tests, just annual screening tests, 2) there is no age limit, so dogs might be used for breeding before they show illness, and 3) the mode of inheritance is unknown and appears complex. The PennVet SCWT DNA Bank contains more than 500 blood or tissue samples from affected dogs as well as geriatric (14 years or older) non-affected Wheatens. Most affected samples are from confirmed PLE and/or PLN cases, with diagnosis documented by blood, urine, and histopathology test results. The proposed study will utilize SNP chip and genome-wide association analysis to identify chromosomal regions that are associated with these serious diseases. Further testing (fine-mapping) of regions of interest may then reveal specific mutations, deletions, or insertions, which could be used to identify carriers of disease-predisposing alleles. We also hope to learn more about the pathogenesis of these diseases (immune-dysregulation vs. structural/functional abnormalities) which may help Wheatens, other breeds of dogs, and humans with these diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.