Displaying results 21 - 30 of 37 items found.
21. 2002 Dog Owners and Breeders Symposium Summaries
(File; Tue Nov 16 07:43:00 CST 2010)
Description: Summaries of the presentions made at the 2002 Dog Owners and Breeders Symposium at the University of Florida College of Veterinary Medicine.
22. Tufts Canine and Feline Breeding and Genetics Conference Summaries
(File; Fri Nov 12 09:59:00 CST 2010)
Description: Presenation summaries from the 2005 Tufts Canine and Feline Breeding and Genetics Conference.
23. Identifying Genes Regulating Addison's Disease in the Portuguese Water Dog (PWD)
(Web Page; Wed Aug 21 09:05:00 CDT 2019)
Description:
Addison's disease, or primary adrenocortical insufficiency, is characterized by destruction of the adrenal cortex, resulting in the inability to produce cortisone when stimulated with the hormone ACTH. In Portuguese Water Dogs (PWDs), this disease occurs with a frequency of 1-2 percent, and is a heritable autoimmune disease of low penetrance, caused by several interacting genes. Using both new and existing data, we propose to identify regions of the PWD genome that contain genes regulating the frequency of Addison's disease. Within those large regions we propose to identify the specific DNA sequence variants that are associated with Addison's. To date we have obtained DNA from about 90 Addisonian PWDs, as well as a number of unaffected PWDs, for which no family history of Addison's is reported. We have already identified two genomic regions, on canine chromosomes 12 and 37, that appear to be associated with the disease. To identify candidate genes, we will make selections using the newly available canine genome sequence, as well as the more detailed human genome sequence. Once affected gene disease frequency is identified, our long term hope is that prognostic tests can be developed that will aid breeders in selecting the most genetically compatible dogs for future
24. Identifying Genes Regulating Addison's Disease in the Portuguese Water Dog (PWD)
(Web Page; Wed Aug 21 09:05:00 CDT 2019)
Description:
Addison's disease, or primary adrenocortical insufficiency, is characterized by destruction of the adrenal cortex, resulting in the inability to produce cortisone when stimulated with the hormone ACTH. In Portuguese Water Dogs (PWDs), this disease occurs with a frequency of 1-2 percent, and is a heritable autoimmune disease of low penetrance, caused by several interacting genes. Using both new and existing data, we propose to identify regions of the PWD genome that contain genes regulating the frequency of Addison's disease. Within those large regions we propose to identify the specific DNA sequence variants that are associated with Addison's. To date we have obtained DNA from about 90 Addisonian PWDs, as well as a number of unaffected PWDs, for which no family history of Addison's is reported. We have already identified two genomic regions, on canine chromosomes 12 and 37, that appear to be associated with the disease. To identify candidate genes, we will make selections using the newly available canine genome sequence, as well as the more detailed human genome sequence. Once affected gene disease frequency is identified, our long term hope is that prognostic tests can be developed that will aid breeders in selecting the most genetically compatible dogs for future breeding.
25. NEW RESEARCH INSIGHTS INTO CANINE ADDISON'S DISEASE
(Web Page; Tue Jan 25 13:48:00 CST 2022)
Description: Recent publications, ongoing studies, and the latest research into what might trigger the onset of this challenging autoimmune disease will be highlighted.
(Web Page; Fri Aug 16 10:21:00 CDT 2019)
Description:
Background: Canine Addison's disease is a dog's inability to produce one or two hormones due to a deficiency of corticosteriods and mineralocorticoids produced by the adrenal glands. In Nova Scotia Duck Tolling Retrievers (NSDTRs) this disorder is much more common than in the general dog population and is inherited. While genetic studies of NSDTRs with Addison's disease have excluded many candidate genes, researchers are still in search of the causative mutations. Objective: This study is extensively examining the entire canine genome utilizing state-of-the-art technologies in search of areas that are associated with this disease in NSDTRs.
(File; Thu Oct 28 10:17:00 CDT 2010)
Description: The AKC Canine Health Foundation 2007 Annual Report contains audited financials for 2006 and 2007 and the Foundation's accomplishments for the year 2007.
(File; Thu Oct 28 12:16:00 CDT 2010)
Description: The AKC Canine Health Foundation 2008 Annual Report contains audited financials for 2007 and 2008 and the Foundation's accomplishments for the year 2008.
(File; Thu Oct 28 09:24:00 CDT 2010)
Description: The AKC Canine Health Foundation 2000 Annual Report contains audited financials for 1999 and 2000 and the Foundation's accomplishments for the year 2000.
(Web Page; Wed Aug 21 09:05:00 CDT 2019)
Description:
Background: Canine Addison's disease is a late onset disorder caused by deterioration of the adrenal gland cortex and insufficient production of glucocorticoids and mineralocorticoids normally produced by that tissue. These hormones are involved in pathways important to normal body function including energy production, blood pressure, and stress response. Treatment is available but is expensive and life-long. Furthermore, delay in diagnosis and treatment can be fatal. Although hypoadrenocorticism occurs in the general canine population, some breeds show a greater prevalence particularly the Bearded Collie. We have demonstrated that hypoadrenocorticism is highly heritable in this breed and likely reflects the presence of a very small number of susceptibility genes. Objective: The researchers are using the canine single nucleotide polymorphism (SNP) test to perform an extensive genome scan of the DNA from Bearded Collies with the goal of identifying genomic regions associated with hypoadrenocorticism. Identifying probable locations that harbor mutations will allow the characterization of the gene(s) that cause this disease.
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