Displaying results 11 - 20 of 31 items found.

11. Identifying Genes Regulating Addison's Disease in the Portuguese Water Dog (PWD)

(Web Page; Fri Apr 13 08:15:00 CDT 2018)


Addison's disease, or primary adrenocortical insufficiency, is characterized by destruction of the adrenal cortex, resulting in the inability to produce cortisone when stimulated with the hormone ACTH. In Portuguese Water Dogs (PWDs), this disease occurs with a frequency of 1-2 percent, and is a heritable autoimmune disease of low penetrance, caused by several interacting genes. Using both new and existing data, we propose to identify regions of the PWD genome that contain genes regulating the frequency of Addison's disease. Within those large regions we propose to identify the specific DNA sequence variants that are associated with Addison's. To date we have obtained DNA from about 90 Addisonian PWDs, as well as a number of unaffected PWDs, for which no family history of Addison's is reported. We have already identified two genomic regions, on canine chromosomes 12 and 37, that appear to be associated with the disease. To identify candidate genes, we will make selections using the newly available canine genome sequence, as well as the more detailed human genome sequence. Once affected gene disease frequency is identified, our long term hope is that prognostic tests can be developed that will aid breeders in selecting the most genetically compatible dogs for future breeding.

12. Identification and Inheritance of DNA Markers for Addison's Disease

(Web Page; Fri Apr 13 08:15:00 CDT 2018)


The study found that Addison's Disease (AD), the late-onset failure of adrenal gland function, is clearly inherited and appears to be regulated by a single gene that is inherited as an autosomal recessive. Researchers collected DNA samples and pedigrees from 390 Bearded Collies, 533 Standard Poodles and 167 Leonbergers. The samples were from both affected and non-affected dogs. Not enough affected Leonbergers were found, so research could not be completed for this breed. Researchers found that AD equally affects males and females; contrary to the bias in the literature, which stated that females were primarily affected. They also found that the coat color of the dog was not relevant. This study has provided the basis for an important next step: scientists will start screening DNA for a genetic marker. Once that marker is found, a DNA test to determine carriers for the disease can be developed.

13. Discoveries Issue 21

(File; Thu Nov 18 19:59:00 CST 2010)

MISSION The mission of theDISCOVERIESAKC Canine Health Foundationis to develop significant resourcesfor basic and applied healthprograms with emphasis oncanine genetics to improvethe quality of life for dogsand their owners.Issue21One Br...

Description: Article topics include the CHIC DNA Bank, health weight for dogs, the genetic test for hemophilia and more.

14. Genetic Diseases Are Unique to Three Varieties of Poodle

(File; Sun Nov 21 11:52:00 CST 2010)

PURINA Pro ClubPoodle UpdateVol. 8, No. 1 ■ June 2009Genetic Diseases Are Unique to Three Varieties of PoodleGenetic diseases that occur inPoodles are as unique as thethree varieties. In fact, size hasa lot to do with the diseases seen i...

Description: The differences in genetic diseases depending on the size variety of the poodle breed.

15. Health Concern Database

(File; Fri Jan 17 08:15:00 CST 2014)

Name Disease Affenpinscher Club of America Afghan Hound Club of America Airedale Health Foundation Airedale Terrier Club of America Akita Club of America, Inc. Alaskan Malamute Club of America, Inc. American Beauceron Club American Belgi...

Description: Results of 2013 health concern poll.

16. Hypoglycemia Requires Quick Intervention in Toy and Small Breeds

(File; Sun Nov 21 12:31:00 CST 2010)

PURINA Pro ClubChihuahua UpdVol. 8, No. a1 ■tJune e2009Hypoglycemia Requires Quick Intervention in Toy and Small BreedsChihuahua breeder JenniferSmolarz of Chesterfield, Mich.,who breeds under the Whisperprefix, began breeding the toy br...

Description: The signs of hypoglycemia and how to react to hypoglycemic attack in dogs.

17. 2007 National Parent Club Canine Health Conference Summaries

(File; Mon Nov 15 19:29:00 CST 2010)

         2007National Parent ClubCanine Health Conference      AKC Canine Health Foundation                St. Louis, MissouriOctober 19–21, 2007Table of ContentsDay One: Welcome..............................................................

Description: Summaries of the presentations made at the 2007 National Parent Club Canine Health Conference.

18. Megaesophagus Research Focuses on Finding a Genetic Marker

(File; Sun Nov 21 18:33:00 CST 2010)

PURINA Pro ClubGerman Shepherd Dog UpdateVol. 8, No. 1 ■ September 2009Megaesophagus Research Focuses on Finding a Genetic MarkerSheila Metz, who breeds GermanShepherd Dogs under theLindenhill prefix, learned aboutmegaesophagus when a 7-...

Description: Summary of the research being done on megaesophagus, a condition where the esophagus fails to function correctly.

19. Discoveries Issue 27

(File; Fri Nov 19 18:52:00 CST 2010)

missionThe mission of theAKC Canine Health Foundationis to develop significant resourcesfor basic and applied healthprograms with emphasis oncanine genetics to improvethe quality of life for dogsand their owners.DiscoveriesMaking a Diffe...

Description: Article topics include growing smart puppies, the genetic test for Mucopolysaccharidosis (MPS), and more.

20. Discoveries Issue 35

(File; Thu Jan 20 15:10:00 CST 2011)

DiscoveriesIssue 35 • Winter 2011MISSIONThe Foundation is dedicated toadvancing the health of all dogsand their owners by funding soundscientific research and supportingthe dissemination of healthinformation to prevent, treat,and cure ca...

Description: Article topics include Major Histocompatibility Complex and Autoimmune Disease, Pug Dog Encephalitis, the 2010 President's award winners: Dr. Bill and Tina Truesdale and more

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