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Simon G. Gregory, PhD, is an Associate Professor in the Section of Medical Genetics, Department of Medicine at Duke University. Dr. Gregory's role in the Duke Center for Human Genetics (CHG) is to apply the experience gained from leading the mapping of the mouse genome and sequencing human chromosome 1 to elucidating the molecular mechanisms underlying multi-factorial diseases. His primary area of research involves the identific ation of the complex genetic factors that give rise to the development of cardiovascular disease and the detection of genes involved in multiple sclerosis. Dr. Gregory's group is also pioneering the application of high-resolution genomic microarrays for the discovery of chromosomal abnormalities and identification of epigenetic factors associated with human diseases such as cancer and autism. This project aims to correlate copy number profiles and factors such as methylation, with clinical phenotypes and differential levels of gene expression. His areas of special expertise are genome mapping, positional cloning and determining the effect that sequence variation has upon the etiology of genetic disease. Dr. Gregory is also director of the Duke Bioinformatics Workshop, a forum for researchers to gain in-depth experience of using publicly available molecular genomics databases.
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