02559: A Dose Escalation Study of Cannabidiol in Dogs with Epilepsy

Grant Status: Open

Grant Amount: $180,000
Stephanie McGrath, DVM, MS; Colorado State University
May 1, 2019 - April 30, 2022


Breed(s): -All Dogs
Research Program Area: Epilepsy Initiative
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Epilepsy is the most common neurologic condition in dogs. Approximately 20-30% of dogs receiving standard therapy remain uncontrolled for seizures. Additionally, the side effects of the antiepileptic drugs (AED) are often unacceptable. Thus, there is a need for an AED that is efficacious with minimal side effects. Cannabidiol (CBD), a prominent non-psychotropic component of the Cannabis sativa plant, has been shown to have anti-convulsant properties in people, offering potential as a treatment for canine epilepsy. The purpose of this study is to find an effective, safe and tolerable dose to reduce seizures in client-owned dogs with uncontrolled epilepsy. The primary goal of the study is to determine an effective and safe dose of CBD for canine epilepsy. If CBD is effective in decreasing seizure frequency, it has the potential to improve quality of life for dogs with uncontrolled epilepsy.


None at this time.

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