2389-MOU: Characterization of Ventricular Arrhythmias in Rhodesian Ridgebacks
Grant Status: Open
The investigators recently identified a genetic mutation associated with heart arrhythmias in Rhodesian Ridgebacks. Dogs with the mutation appear to be at the most risk of developing an arrhythmia and suffering sudden death between 12-24 months of age, however, this timeline is variable, and some dogs appear to outgrow the arrhythmia. Due to the lack of knowledge of the specific at-risk age, owners of dogs with the mutation must repeat the Holter monitor (a test to monitor heart rhythm) every few months to identify when their dog is at greatest risk and may need treatment. The objective of this study is to repeatedly perform regular Holter monitor testing on dogs with the mutation (including dogs with one copy and with two copies) every 4 months from 6-24 months of age with a final evaluation at 36 months to narrow in on the age when the arrhythmias appear to be the most severe. Gaining this increased clinical understanding of the disorder will decrease the risk of sudden death by helping owners and veterinarians in monitoring and providing treatment intervention for their dogs, and will further inform breeders and owners by characterizing the clinical and genetic manifestations of the disorder.
Funding for the research is provided through the collaborative efforts and generosity of the Rhodesian Ridgeback Charitable Foundation. The AKC Canine Health Foundation supports the funding of this effort and will oversee grant administration and scientific progress reports.
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