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2012 Oak Grants

In September 2011, the AKC Canine Health Foundation Board of Directors approved over $1.5 million in new grants to commence in 2012.  To see the abstract, amount and time period for each grant click on the link below each grant.

To support any of these research projects, please consider donating or sponsoring today!

Grant 1557: High-Resolution Cytogenetic Analysis of Histiocytic Malignancies and Development of a Targeted Assay to Screen for Expression Level Changes
Dr. Matthew Breen, PhD; North Carolina State University
Project Goal: The goal of this project is to narrow down the search for genes playing a key role in Histiocytic Malignancies and thus move a step closer to developing targeted therapies for canine patients diagnosed with this devastating cancer.
View Grant 1557

Grant 1569:  Evaluation of GS-9219 in Canine Cutaneous Lymphoma
Dr. Douglas H Thamm, VMD: Colorado State University
Project Goal:  This clinical trial aims to determine if the novel cancer drug GS-9210 is effective in fighting canine cutaneous T cell lymphoma.

Grant 1572:  Targeting Neutrophil Activation to Develop Novel Drugs to Treat Respiratory Tract Inflammation in Dogs
Dr. Samuel L. Jones, DVM, PhD; North Carolina State University
Project Goal:  This research group has developed a new compound called the MANS peptide.  The goal of the project is to determine if MANS peptide can be used to treat serious inflammatory diseases of the canine respiratory tract.
View Grant 1572

Grant 1577:  Fine Mapping of Loci for Transitional Cell Carcinoma in the Scottish Terrier, West Highland White Terrier, and Shetland Sheepdog
Dr. Elaine Ostrander, PhD; National Human Genome Research Institution
Project Goal: The goal of this project is to find the gene mutation that is responsible for Transitional Cell Carcinoma, a type of bladder cancer, in three breeds of dogs with higher risk for the disease.

Grant 1584:  Conformation in Cranial Cruciate Ligament Deficiency in Dogs
Dr. Dominique J. Griffon, DVM PhD; Western University of Health Sciences
Project Goal: The goal of this project is to understand the relationship between genetics, body characteristics and Cranial Cruciate Ligament Deficiency (CCLD) in dogs.  Indentifying which dogs are predisposed to the disease is a crucial first step to reducing risk or delaying onset of CCLD.

Grant 1585:  Phase I Study of Involved-Field Radiotherapy (IFRT) for Advanced Stage Canine Lymphoma
Dr. Michael Deveau, DVM, MS; Texas A&M University
Project Goal: The goal of this phase I clinical trial is to determine the safety of treating canine lymphoma with Involved-Field Radiotherapy using helical tomotherapy.  This treatment is being used in human medicine and needs to be evauluated for use in veterinary medicine.
View Grant 1585

Grant 1586:  Genome Wide Association Analysis for Sebaceous Adenitis in Havanese Dogs
Dr. Sandra N. Koch, DVM; University of Minnesota
Project Goal: The ultimate goal of this study is to develop DNA-based tests for susceptibility to the inflammatory skin disease sebaceous adenitis that would be used for diagnostic confirmation; in breeding decisions to help reduce the incidence of the disease; and potentially develop more specific therapies for the disorder.

Grant 1591:  Discovery of Genetic Susceptibility Loci in Atopic Dermatitis using a Genome-Wide Association Study in West Highland White Terriers
Dr. Natasha J Olby, VetMB PhD; North Carolina State University
Project Goal:  This research team will conducat a genome wide association study of Atopic Dermatitis in Westies to identify chromosomal regions associated with the disease. The long-term goal is to develop genetic tests that can be used by breeders to decrease the prevalence of this condition.
View Grant 1591

Grant 1592:  Investigation into the Genetics of Scottie Cramp: Sequencing of Associated Chromosomal Regions
Dr. Natasha J Olby, VetMB PhD; North Carolina State University
Project Goal:  Following up on previous reserach funded by CHF, the goal of this project is to use deep sequencing techniques to identify genetic mutations associated with Scottie Cramp. 
View Grant 1592

Grant 1594:  Genetic Analysis of Familial Glaucoma in the Basset Hound
Dr. Markus H. Kuehn, Ph.D.; University of Iowa
Project Goal: Primary angle closure glaucoma appears to be an inherited autosomal recessive trait in Basset Hounds.  The goal of this project is to map and identify the disease gene so breeders will have the tools to identify dogs carrying the disease gene.
View Grant 1594

Grant 1601:  Unraveling the Genetic Background of Intrahepatic Portosystemic Shunt in Irish Wolfhounds
Dr. Peter A.J. Leegwater, PhD; University of Utrecht
Project Goal: Intrahepatic portosystemic shunt is a liver disease that is hereditary in Irish Wolfhounds.  The goal of this project is to identify the genes responsible for the disorder and develop a test that will help breeders reduce the incidence of the disease.
View Grant 1601

Grant 1602:  Longitudinal Study Investigating the Progression and Pathogenesis of Atypical Hyperadrenocorticism in Scottish Terriers
Dr. Kurt Zimmerman, DVM PhD; Virginia-Maryland Regional College of Veterinary Medicine
Project Goal: This research group will use a combination of traditional laboratory, functional and genetic tests to try understand why Scottish Terriers are predisposed to developing atypical Hyperadrenocorticism and how best to treat and screen for the disorder.
View Grant 1602

Grant 1609:  Probiotic VSL# 3 Reduces Enteritis in Dogs with Inflammatory Bowel Disease
Dr. Albert E. Jergens, DVM, PhD; Iowa State University
Project Goal: Idiopathic inflammatory bowel disease (IBD) is a common cause of gastrointestinal disease in dogs.  This study will help to determine if probiotic therapy is effective and can be applied to widespread clinical use.  The study will be beneficial for the treatement of both canine and human IBD.
View Grant 1609

Grant 1612:  Use of Modified Cyclosporin A to Improve Cataract Surgery Outcomes
Dr. Heather Chandler, PhD; Ohio State University
Project Goal: Posterior capsular opacification is a complication of cataract surgery that causes secondary vision loss.  This project will evaluate the use of the drug Cyclosporin A to prevent this complication in hopes of improving the veterinary ophthalmologists options for restoring long-term vision.
View Grant 1612

Grant 1615:  Identification of Idiopathic Epilepsy Genes in Australian Shepherds
Dr. Ned E. Patterson, DVM PhD; University of Minnesota
Project Goal: This research group aims to identify the genetic mutation associated with epilepsy in Australian Shepherds and develop a DNA based test to identify affected dogs and aid in diagnosis.  After identifying a mutation, the researchers will also test to see if the mutation(s) affect other dog breeds with a high incidence of epilepsy.
View Grant 1615

Grant 1620:  Clinical and Laboratory Efficacy and Safety Studies of T-Cell Receptor (TCR) Peptides in Canine Atopic Dermatitis
Dr. Daniel A. Gingerich, DVM; Imulan Bio Therapeutics, LLC
Project Goal: The purpose of this study is to confirm efficacy and safety of TCR peptide treatment in dogs with the frustrating and chronically relapsing skin disease, atopic dermatitis. 
View Grant 1620

Grant 1633:  Phase I S100B Inhibitor Clinical Trial for Canine Melanoma Therapy
Dr. Heather M. Wilson, DVM; Texas A&M University
Project Goal: This study is a collaborative effort between basic scientists and clinicians to determine if combined pentamidine/chloropromazine therapy is safe for canine melanoma patients.  These drugs are currently used in veterinary medicine to treat other diseases, so the probability is high that they will be safe for melanoma treatment and improve survival for dogs with melanoma.
View Grant 1633

Grant 1651:  Serum Antibody Reactivity Profiling for Canine Lymphoma Detection and Monitoring
Dr. Stephen A Johnston, PhD; Arizona State University
Project Goal: Most canine lymphoma patients respond to chemotherapy but eventually relapse.  This project is meant to investigate serum immunoproteomic profiling for monitoring of remission status in dogs with lymphoma. 
View Grant 1651

Grant 1657:  Defining New Therapeutic Approaches for Osteosarcoma through Genome Wide Screening and Comparative Oncology
Dr. Carl Walkley; St Vincent's Institute of Medical Research
Project Goal: This project uses high-throughput screening technology (siRNA libraries) in human and dog osteosarcoma cells in combination with the chemotherapy drug doxorubicin.  The researchers will be looking for the individual genes that are silenced by siRNA and improve the response to doxorubicin.
View Grant 1657

Grant 1658:  Urinary Protein and Gene Expression Characterization and Comparison with Renal Biopsy Findings and Clinical Data in Dogs with Proteinuric Renal Diseases
Dr. Mary B Nabity, DVM, PhD; Texas A&M University
Project Goal:  The purpose of this study is to evaluate promising indicators of kidney injury that might improve the detection and/or assesment of progression in dogs with chronic kidney disease.  The results can be evaluated to determine if the novel tests are more accurate and less invasive for assessing kidney damage in dogs.
View Grant 1658

Grant 1660:  Alternative Genetic Approaches for Identifying Canine Osteosarcoma Genes
Dr. Carlos E. Alvarez, PhD; Ohio State University College of Medicine
Project Goal: This research group will use an innovative genetic approach that enables genome-wide discovery of the genetic variations in Greyhounds to assess risk for osteosarcoma.  Findings on the genetic risk for osteosarcoma would lead to rapid development of therapies and clinical trials for dogs with translation to human medicine.

To support any of these research projects, please consider donating or sponsoring today!