640: Linkage Disequilibrium Analysis of Markers Associated with Pug Dog Encephalitis
Grant Status: Closed
AbstractThe long-term goal of the proposed research is to understand the molecular genetics of breed specific necrotizing meningoencephalitis in the Pug (Pug Dog Encephalitis, or PDE). Although the cause of PDE is currently unknown, the breed predilection strongly suggests a genetic component. A necessary resource for this goal is detailed information regarding the incidence and inheritance of PDE, as well as extensive biological sampling and detailed medical histories. To this end, we have collected biological samples, detailed medical histories, and pedigrees to create the largest information database currently in existence for PDE. We propose to carry out whole genome scans for identification of a specific region of the genome that may be involved in PDE. These scans will survey the entire canine genome for areas potentially associated with PDE. Once candidate regions are identified, we will then narrow the region to a specific gene that may be causing PDE, eventually leading to the development of carrier detection tests.
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