640: Linkage Disequilibrium Analysis of Markers Associated with Pug Dog Encephalitis

Grant Status: Closed

Grant Amount: $49,464
Kimberly A Greer, PhD; Texas A&M University
December 1, 2006 - November 30, 2008


Breed(s): Pug
Research Program Area: Neurology
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The long-term goal of the proposed research is to understand the molecular genetics of breed specific necrotizing meningoencephalitis in the Pug (Pug Dog Encephalitis, or PDE). Although the cause of PDE is currently unknown, the breed predilection strongly suggests a genetic component. A necessary resource for this goal is detailed information regarding the incidence and inheritance of PDE, as well as extensive biological sampling and detailed medical histories. To this end, we have collected biological samples, detailed medical histories, and pedigrees to create the largest information database currently in existence for PDE. We propose to carry out whole genome scans for identification of a specific region of the genome that may be involved in PDE. These scans will survey the entire canine genome for areas potentially associated with PDE. Once candidate regions are identified, we will then narrow the region to a specific gene that may be causing PDE, eventually leading to the development of carrier detection tests.


Greer, K. A., Wong, A. K., Liu, H., Famula, T. R., Pedersen, N. C., Ruhe, A., … Neff, M. W. (2010). Necrotizing meningoencephalitis of Pug Dogs associates with dog leukocyte antigen class II and resembles acute variant forms of multiple sclerosis. Tissue Antigens. https://doi.org/10.1111/j.1399-0039.2010.01484.x
Greer, Kimberly A., Schatzberg, S. J., Porter, B. F., Jones, K. A., Famula, T. R., & Murphy, K. E. (2009). Heritability and transmission analysis of necrotizing meningoencephalitis in the Pug. Research in Veterinary Science, 86(3), 438–442. https://doi.org/10.1016/j.rvsc.2008.10.002
Levine, J. M., Fosgate, G. T., Porter, B., Schatzberg, S. J., & Greer, K. (2008). Epidemiology of Necrotizing Meningoencephalitis in Pug Dogs. Journal of Veterinary Internal Medicine, 22(4), 961–968. https://doi.org/10.1111/j.1939-1676.2008.0137.x
Young, B. D., Levine, J. M., Fosgate, G. T., de Lahunta, A., Flegel, T., Matiasek, K., … Schatzberg, S. J. (2009). Magnetic Resonance Imaging Characteristics of Necrotizing Meningoencephalitis in Pug Dogs. Journal of Veterinary Internal Medicine, 23(3), 527–535. https://doi.org/10.1111/j.1939-1676.2009.0306.x

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