00368-A: Effects of Early Environmental Conditions on Duration of Immunity in Puppies
Grant Status: Closed
AbstractThe proposed study will determine the minimal doses of vaccine necessary to immunize and maintain acceptable antibody titer level during adulthood in puppies exposed to different environmental conditions. The animals within the study will be 90 healthy puppies 12 weeks old or less. The puppies will be selected from 3 population groups. One group will consist of 30 client owned dogs that are presented for routine immunization to the Community Practice Service of Auburn University's veterinary teaching hospital; the second group will consist of 30 puppies that have been presented to the Lee County Humane Shelter that are determined adoptable based on recommendations of shelter staff and physical examination by a veterinarian; and the third group will consist of 30 puppies born of Canine Detection and Research Center dams now located in Anniston, AL and fostered in private homes in the area for socialization prior to future use in Canine Detection and Research Institute (CDRI) programs. Immunity will be determined by antibody titers in the blood. Blood samples for antibody titer assay will be collected from each puppy and submitted to Auburn University Virology Laboratory. Adequate antibody titers will be determined by a standard virus neutralization assay. Antibody titers of 1:40 or greater against Canine Distemper Virus (CDV), Canine Adenovirus-2 (CAV-2) and Canine Parvovirus (CPV) are accepted as indicators of immunity. The difference in antibody titers between the groups will be statistically compared. The proposed study will determine the minimal doses of vaccine necessary to immunize and maintain protection during adulthood in puppies exposed to different environmental conditions.
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Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.