02608-A: Identification of Genetic Risk Factors for Primary Closed Angle Glaucoma and Pectinate Ligament Abnormality in the Basset Hound

Grant Status: Open

Grant Amount: $14,750
Cathryn Mellersh, PhD; Animal Health Trust
March 1, 2019 - February 28, 2021
Breed(s): Basset Hound
Research Program Area: Ophthalmology

Abstract

Primary glaucoma is a painful and blinding disease associated with abnormally high intraocular pressure. Treatment in dogs is usually unsuccessful, and most affected dogs ultimately require removal of their eyes. The most common form of canine primary glaucoma is primary closed angle glaucoma (PCAG) which is significantly associated with pectinate ligament abnormality (PLA), also referred to as pectinate ligament dysplasia (PLD), an abnormality affecting the drainage angle of the eye. PCAG and PLA are prevalent in several breeds, and PLA is highly heritable. Not all dogs with PLA develop glaucoma, however, indicating that the inheritance of PCAG is complex. This complex inheritance and the progressive nature of PLA mean that breeding strategies based on ophthalmic examinations alone are unlikely to be sufficient to eliminate the disease. PCAG and PLA appear to be prevalent in the Basset Hound (BH) both in Europe and the U.S. Two genetic regions have been identified in the BH which are strongly associated with PCAG but not with PLA in European and USA BH dogs. This study will sequence the genomes of European and USA BH dogs with PCAG and PLA to identify variants that segregate with PCAG (and not PLA). Follow-up on PCAG candidate variants in large cohorts of European and USA BH will be performed to confirm association with disease in the breed. The ultimate aim is to develop DNA tests for PCAG in the BH that will reduce disease prevalence when used in parallel with breed-specific guidance for breeders while simultaneously allowing for breeding of BH with PLA that are not at risk of PCAG.

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