02520-MOU: Identification of Genetic Markers for Familial Subvalvular Aortic Stenosis in Rottweilers

Grant Status: Open

Grant Amount: $44,320
Dr. Joshua A Stern, DVM, PhD, University of California, Davis
February 1, 2018 - January 31, 2020
Breed(s): Rottweiler
Research Program Area: Cardiology


Subvalvular Aortic Stenosis (SAS) is a heart defect characterized by a fibrous ridge located below the aortic valve. Affected dogs are at risk of developing heart valve infections, congestive heart failure or sudden death. Severely affected dogs have an average lifespan of 19 months. SAS is an inherited heart problem reported in Rottweilers. The goal of this research is to identify causative genetic mutations and develop a reliable genetic test for this condition in Rottweilers, to aid breeders in making informed decisions to reduce the prevalence of this condition. Once a chromosomal region of interest is identified via a genome wide association study (GWAS), whole genome sequencing (WGS) will be employed to identify variants associated with SAS. The top variants identified via WGS will be submitted for Sequenom analysis to prioritize variant pursuit.

Funding for the research is provided through the collaborative efforts and generosity of the Rottweiler Health Foundation. The AKC Canine Health Foundation supports the funding of this effort and will oversee grant administration scientific progress reports.


None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Make an Investment Today:

  • $50
  • $100
  • $250
  • $1000
  • Give Now
Connect With Us:
Get Canine Health News:
Please leave this field empty

© 2016 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software