2465: Identification and Characterization of Genetic Mutations in Canine Mast Cell Tumors
Grant Status: Closed
AbstractThe most common malignant tumor in dogs is the mast cell tumor (MCT, a form of skin cancer), occurring with an incidence of close to 20 percent in the canine population. MCTs range from relatively benign to extremely aggressive, leading to tumor spread and eventual death. Particular breeds of dog are at risk for the development of this tumor, indicating a role for genetic factors. We have previously identified mutations in the gene c-kit in 30-50 percent of dog MCTs. c-Kit plays a critical role in regulating the growth and function of normal mast cells, and as the mutations we discovered cause uncontrolled function of c-kit, it is likely they influence MCT development in dogs. This proposal will establish a prospective tumor registry of dog MCTs to be used for investigation of the true incidence of c-kit mutations within specific dog breeds. Moreover, the studies outlined in this grant will identify additional genetic mutations present in dog MCTs that can be used for the development of new targeted therapeutics. In summary, this work will provide a much more detailed understanding of dog MCTs, thereby building a framework for the development of new therapies and strategies for disease prevention.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.