2416: Systemic Inflammatory Response Syndrome in Canine Pyometra

Grant Status: Closed

Grant Amount: $6,596
Boel Fransson, DVM; Washington State University
April 1, 2003 - March 31, 2004

Sponsor(s): Bulldog Club of America Charitable Health Fund, Inc., Chow Chow Club, Inc., English Setter Association of America, Inc.

Breed(s): -All Dogs
Research Program Area: Reproductive Conditions
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Early recognition and aggressive treatment of the Systemic Inflammatory Response Syndrome (SIRS) is imperative to avoid a fatal outcome. SIRS is not a disease in itself but is considered as the overwhelming response of the body to a cascade of inflammatory mediators, released after major trauma, pancreatitis, snake bite, heat stroke or bacterial infection of different organs. Pyometra, a common disease in intact female dogs, is considered associated with SIRS. Our cooperation with the Swedish University of Agricultural Science in Sweden, where female dogs are not routinely spayed, gives us an unique opportunity to receive large numbers of samples from dogs with pyometra. Blood samples from 50 dogs have been successfully transported to WSU. Detection of SIRS today is limited to recognition of clinical criteria, defined for SIRS, such as temperature, heart rate, and white blood cell count, but these criteria are not very specific. The proposed study will test if cytokine and acute phase protein levels in the blood are more specific detectors of SIRS than clinical criteria, which could lead to a more accurate and rapid detection of this syndrome. Rapid recognition would enable institution of aggressive treatment earlier in the disease, likely leading to reduced suffering and mortality of these dogs.


Fransson, B. A., Karlstam, E., Bergstrom, A., Lagerstedt, A.-S., Park, J. S., Evans, M. A., & Ragle, C. A. (2004). C-reactive Protein in the Differentiation of Pyometra From Cystic Endometrial Hyperplasia/Mucometra in Dogs. Journal of the American Animal Hospital Association, 40(5), 391–399. https://doi.org/10.5326/0400391

Fransson, B. A., Lagerstedt, A.-S., Bergstrom, A., Hagman, R., Park, J. S., Chew, B. P., … Ragle, C. A. (2007). C-reactive protein, tumor necrosis factor α, and interleukin-6 in dogs with pyometra and SIRS. Journal of Veterinary Emergency and Critical Care, 17(4), 373–381. https://doi.org/10.1111/j.1476-4431.2006.00203.x

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