1817: Genetics of Malignant Histiocytomas in the Flat-Coated Retriever

Grant Status: Closed

Grant Amount: $48,128
Dr. Terri M. King, PhD, University of Texas
September 14, 1999 - September 13, 2001
Sponsor(s): Flat-Coated Retriever Foundation
Breed(s): Flat-Coated Retriever
Research Program Area: Prevention

Abstract

Why do Flat Coated Retrievers (FCR) get cancer? This is a question that has been asked repeatedly over the last several years. To answer this question, we have established a tumor registry at The Ohio State University. From this registry, we have found that FCR develop a particular type of cancer called malignant fibrous histiocytomas (MFH). We suspect that FCR have an inherited susceptibility to this cancer. This study will investigate the role of genetics in the development of MFH. We will begin by identifying FCRs with MFH from the Tumor Registry. We will then collect health information, blood samples and pedigrees from the parents, siblings and offspring of the affected animals. From this information, we will look at how MFH is transmitted in families. By looking at the patterns of transmission, we will begin to understand the genetics. We are also storing the blood in anticipation of studies to localize the genes that are associated with the development of MFH. The goal of this research is to begin to answer that very important question above and to work toward preventing this disease.

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