1626: Significance of Tumor Suppressor Genes in Canine Cancer
Grant Status: Closed
The research conducted in this study will provide the basis for future research that may, ultimately, lead to scientists being able to provide a better assessment of individuals risks for cancer (or for cancer in progeny), as well as determine whether a given dog is a good candidate for a given therapy. This project has helped to broaden the understanding of why tumors happen, so that the abnormalities can be targeted and better therapies devised. Researchers developed and tested gene therapy for melanoma. In a clinical trial involving five dogs with facial or oral melanoma, they found that the gene therapy, in which tumors were injected with modified genes, was both free of adverse effects and effective.
Bianco, S. R., Sun, J., Fosmire, S. P., Hance, K., Padilla, M. L., Ritt, M. G., … Modiano, J. F. (2003). Enhancing antimelanoma immune responses through apoptosis. Cancer Gene Therapy, 10(9), 726–736. https://doi.org/10.1038/sj.cgt.7700625
Dickerson, E. B., Thomas, R., Fosmire, S. P., Lamerato-Kozicki, A. R., Bianco, S. R., Wojcieszyn, J. W., … Modiano, J. F. (2005). Mutations of Phosphatase and Tensin Homolog Deleted from Chromosome 10 in Canine Hemangiosarcoma. Veterinary Pathology, 42(5), 618–632. https://doi.org/10.1354/vp.42-5-618
Fosmire, S. P., Thomas, R., Jubala, C. M., Wojcieszyn, J. W., Valli, V. E. O., Getzy, D. M., … Modiano, J. F. (2007). Inactivation of the p16 Cyclin-Dependent Kinase Inhibitor in High-Grade Canine Non-Hodgkin’s T-Cell Lymphoma. Veterinary Pathology, 44(4), 467–478. https://doi.org/10.1354/vp.44-4-467
Jubala, C. M., Wojcieszyn, J. W., Valli, V. E. O., Getzy, D. M., Fosmire, S. P., Coffey, D., … Modiano, J. F. (2005). CD20 Expression in Normal Canine B Cells and in Canine non-Hodgkin Lymphoma. Veterinary Pathology, 42(4), 468–476. https://doi.org/10.1354/vp.42-4-468
Modiano, J. F., Breen, M., Burnett, R. C., Parker, H. G., Inusah, S., Thomas, R., … Avery, A. C. (2005). Distinct B-Cell and T-Cell Lymphoproliferative Disease Prevalence among Dog Breeds Indicates Heritable Risk. Cancer Research, 65(13), 5654–5661. https://doi.org/10.1158/0008-5472.CAN-04-4613
Ritt, M. G., Mayor, J., Wojcieszyn, J., Smith, R., Barton, C. L., & Modiano, J. F. (2000). Sustained nuclear localization of p21/WAF-1 upon growth arrest induced by contact inhibition. Cancer Letters, 158(1), 73–84. https://doi.org/10.1016/S0304-3835(00)00507-3
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.