1407: Idiopathic Epilepsy in Poodles: Determining Mode(s) of Inheritance
Grant Status: Closed
Project SummaryThe pedigree analysis of one large family of Standard Poodles showed that the mode of inheritance for idiopathic epilepsy in that family is most likely recessive, though the research is not yet conclusive. Pedigree analysis of another large family looks potentially recessive, but the pattern is less clear. An additional contribution of this research was the development of a reliable system for classifying canine seizures. Using this system, the researchers found that the vast majority of affected dogs studied have seizures that begin in one hemisphere of the brain (focal seizures). This could have implications for treatment and for identification of the genes involved in canine epilepsy. The seizure classification system developed under the grant also may help future epilepsy researchers: it could apply to all breeds and be helpful in various types of canine epilepsy research.
Licht, B. G., Lin, S., Luo, Y., Hyson, L. L., Licht, M. H., Harper, K. M., . . . Johnston, E. V. (2007). Clinical characteristics and mode of inheritance of familial focal seizures in Standard Poodles. J Am Vet Med Assoc, 231(10), 1520-1528. doi:10.2460/javma.231.10.1520
Licht, B. G., Licht, M. H., Harper, K. M., Lin, S., Curtin, J. J., Hyson, L. L., & Willard, K. (2002). Clinical presentations of naturally occurring canine seizures: similarities to human seizures. Epilepsy Behav, 3(5), 460-470. doi:10.1016/s1525-5050(02)00523-1
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