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The genetics of injury to the cranial cruciate ligament in Newfoundlands and related breeds of dog
We are studying an orthopedic condition, cranial cruciate ligament rupture (CCLR), that causes hind limb lameness in nearly 20% of dogs. The study hypothesis is that mutations may exist in genes predisposing some dogs to CCLR. Newfoundland dogs and related breeds (labs) are the focus of this study because they are at high risk for CCL injury, and previous study has shown that this is a hereditary condition. Currently looking for Labrador Retrievers, with and without CCLR We are collecting blood samples for DNA from these breeds which are affected and unaffected with CCLR. These samples will be searched for genetic markers that may serve as disease predictors. These markers will then allow identification of carriers of CCLR, and potentially the reduction or elimination of CCLR from the dog population.
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