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Cancer is a major cause of death in older dogs and treatment is often ineffective. We wish to identify the causes of cancer in order to learn how to more effectively predict, prevent, and treat the disease. Genetic (heritable) factors are important in the development of Transitional cell carcinoma (TCC) of the bladder. The Scottish and West Highland White terriers and the Shetland sheepdog are at high risk for TCC, suggesting that subsets of dogs from each of these breeds are born with errors in critical genes that predispose them to TCC. We wish to develop ways to identify the dogs with genetic risk factors for TCC before they get the disease. Dogs at risk could then either enter cancer prevention trials, undergo screening tests to detect cancer at its earliest state, and, in the future, possibly receive “genetic” therapy. We have found two regions of the genome where error-prone genes lie and have narrowed the first region to a few hundred bases in an interval that has only two genes. We are requesting continued support to allow us to find this mutation as well as fine map the remaining critical gene(s). To do this we need blood samples from dogs that have been diagnosed with TCC of the bladder as well as healthy dogs over the age of 10 that have never had any form of cancer.More Information
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Your help is needed with canine health research. DNA and tissue samples are needed from healthy dogs and dogs affected by certain diseases.