Samples Needed from Serveral Breeds affected by Hemangiosarcoma

11/05/2013
Breed(s): German Shepherd Dog, Leonberger, Irish Wolfhound, Labrador Retriever, Boxer, Golden Retriever
Study Type: Blood Sample
Study Location: Broad Institute

The Broad Institute and collaborators are working on identifying disease genes predisposing to cancer. Identification of such genes could lead to carrier testing, a better understanding of the disease and long term better treatments for the disease in both dogs and humans. More information can be found at their website. The researchers need blood samples from affected dogs as well as blood samples from healthy older (> 8 yo) dogs.

Hemangiosarcoma (HSA) are rapidly growing and highly invasive blood filled tumors. Blood vessels grow from the tumor and often cause death through excessive blood loss due to rupturing of the tumor.

In a so called genome-wide association (GWA) study of HSA in golden retriever we have been able to identify several regions of the genome that are associated with HSA risk using >100 cases and >100 controls. Further analysis of these risk regions is now teaching us about the disease mutations and how the mutations cause disease. To confirm the effect of these risk factors we also want to screen a much larger population of healthy and affected golden retrievers.

In addition, we want to study the golden retriever mutations in other breeds to see if the same mutations contribute to disease risk for additional breeds. In parallel we want to collect enough dogs (~100 cases and ~100 controls) from other breeds to find genetic risk factors in each breed. We would therefore be very grateful for samples from dogs from multiple breeds.

Our overall goal is to find the risk factors and disease mechanism in many breeds with the hope to help develop better treatment options in the future.

More Information

 

Contact Information:
Name: Michele Perloski
Email: Perloski@broadinstitute.org
Website: www.dogDNA.org
Phone: 617-714-7792

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