Samples Needed from Dachshunds, Pugs, Chihuahuas, Boston Terriers, and Miniature Pinschers who have been Recently Vaccinated

Breed(s): Boston Terrier, Chihuahua, Dachshund, Miniature Pinscher, Pug
Study Type: Blood Sample
Study Location: Purdue University

Allergic reactions continue to be the most common adverse event associated with vaccination in dogs. Recent research has demonstrated that small dogs in general, and several specific breeds, are at higher risk for these reactions. Laboratory studies have shown that normal dogs make antibodies against many vaccine components, even though they may not show an allergic reaction immediately following vaccination. Although the specific cause of allergic reactions in dogs remains unknown, vaccine components residual from the manufacturing process have been incriminated.

Dr. George Moore at the Purdue University School of Veterinary Medicine - funded by the AKC Canine Health Foundation - continues to to identify causes of vaccine-induced allergic reactions. Using serum from dogs of high-risk breeds, this project compares antibody concentrations in dogs demonstrating allergic reactions versus antibody concentrations in dogs of the same breed that don't have reactions.

Although the original CHF grant is completed, the researchers continue to gather samples from 5 high-risk breeds including the Dachshund, Pug dog, Chihuahua, Boston Terrier, and Miniature Pinscher. Your dog may participate in this study if they are a member of this group, and have been vaccinated in the past three weeks. Two (2) ml of serum are needed per dog for the analyses, necessitating withdrawal of approximately 4-5 ml of blood. Samples may be taken from affected dogs as soon as clinical signs of an allergic reaction develop, or within 3 weeks thereafter. Samples may be taken from non-affected dogs as soon as the day following vaccination, or within 3 weeks thereafter. For samples from dogs that meet the eligibility criteria, veterinarians can email the investigators or visit their website.

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