Samples Needed for Addison’s Disease Study

01/26/2015
Breed(s): -All Dogs, Standard Poodle
Study Type: Blood Sample
Study Location: North Carolina State University

Addison's disease is an endocrine disorder where the body attacks its own adrenal glands. The adrenal glands make important hormones that help us cope with stress and control electrolyte balance, among other things. In Addison's disease, the adrenal glands stop producing these hormones and leave us susceptible to a range of problems ranging from severe dehydration to gastrointestinal signs to abnormal heart rhythms. Because the signs associated with Addison's disease can be vague, the condition is often misdiagnosed and can cause significant problems in both people and dogs. Addison's disease is inherited in Standard Poodles, but the genetics of the disease are unknown.

Principal Investigators Dr. Steven Friedenberg, Dr. Kathryn Meurs, and Dr. Katharine Lunn hope that by taking advantage of major advances in DNA sequencing, they can uncover the gene mutations that cause this disease in Standard Poodles, and potentially other breeds as well. By finding the mutations, they can work to decrease the incidence of the disease in this breed. They also hope to apply what they discover to other dog breeds and to humans, where the genetics of the disease remain a mystery as well.

More Information

 

Contact Information:
Name: Dr. Steven Friedenberg
Email: steven_friedenberg@ncsu.edu
Phone: 919-515-3277

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