Medium to Large Breed Dogs with Cruciate Ligament Rupture
The Small Animal Orthopaedic Service at the University of Wisconsin School of Veterinary Medicine is looking for medium to large breed dogs with unilateral non-contact cruciate rupture to participate in a trial evaluating a regenerative medicine treatment with platelet-rich plasma (PRP) as a preventative treatment for early disease and stable partial cruciate rupture. At the time of tibial plateau leveling osteotomy (TPLO) treatment of the knee with cruciate rupture, the contralateral second knee with stable partial cruciate rupture will be treated with PRP. It is anticipated that this treatment will reduce joint inflammation and promote healing of the cruciate ligament complex. If the dog qualifies for entry into the study, we will obtain the following:
- Radiographs and MRI images of the knees
- Blood samples
- Tissue biopsies from both knees at the time of surgical treatment
Recheck visits will be set up at 10 weeks and 12 months after surgery for additional imaging of the knees.
For dogs enrolled in the study, free MRI images of the knees will be made at the Small Animal Orthopaedic Service at UW Veterinary Care, University of Wisconsin-Madison. In addition, all dogs will receive the regenerative medicine treatment. Treatment costs for TPLO will be subsidized. This trial is actively enrolling patients.
More information is available in this flyer.
This study is supported by AKC Canine Health Foundation Grant 1762.More Information
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