Mast Cell Tumor Samples Needed

11/05/2013
Breed(s): Rhodesian Ridgeback, German Shepherd Dog, Chinese Shar-Pei, Labrador Retriever, Pug, Boxer, Golden Retriever
Study Type: Blood Sample
Study Location: Broad Institute

The Broad Institute and collaborators are working on identifying disease genes predisposing to mast cell tumors.

Mast cell tumors (MCT) are cancerous proliferations of mast cells. Although they can and will spread throughout the body, the danger from MCTs comes from the secondary damage caused by the release of histamine and other immunological molecules from the tumors. These chemicals can cause systemic problems that include gastric ulcers, internal bleeding, and a range of allergic manifestations.

We have compared the genomes of 88 Golden Retrievers with MCT and 103 healthy Golden Retrievers and are very excited to have identified several regions of the genome that appear to be inherited risk factors for mast cell tumors in Golden Retrievers. We are now validating these results in more dogs and looking to identify the exact gene and mutation.

We have also found genetic risk factors for mast cell tumors in boxers and Labrador retrievers, but these studies need more samples and further analysis before completion.

We are therefore looking for samples from many breeds to be able to continue to learn about the disease mechanisms causing mast cell tumors in dogs.

More Information

 

Contact Information:
Name: Michele Perloski
Email: perloski@broadinstitue.org
Website: www.dogDNA.org
Phone: 617-714-7792

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