Immune targeting of the V600E B-Raf neo-antigen in canine urothelial carcinoma
Bladder cancer or urothelial carcinoma (UC) affects approximately 40,000 dogs per year in the US with specific breeds including Scottish Terriers, West Highland White Terriers, Shetland Sheepdogs, Beagles, and Parson Russell Terriers being over-represented. Affected dogs usually display lower urinary tract clinical signs including bloody urine, frequent urination, difficulty and pain on urinating, and urinary outflow tract obstructions. Standard of care consists of anti-inflammatory drugs either alone or in combination with chemotherapy or radiation therapy. While these treatments can lead to stable disease for 6-12 months, they rarely lead to a cure, and most dogs eventually succumb to their disease. In human medicine, urinary bladder tumors have been shown to exhibit a high gene mutational burden which directly correlates with a favorable response to immune therapies. Canine UC exhibits a similar mutational load suggesting that the disease in dogs may also be immune responsive.
Researchers at the University of Pennsylvania are conducting a clinical trial investigating a bacterial vaccine that encourages the immune system to target the V600E B-Raf protein, which is found in up to 87% of dogs with TCC. The goal is to determine if this vaccine is safe, and if it can delay tumor growth or spread and extend survival in dogs with this disease.
• Dogs with TCC of the bladder that is positive for V600 BRAF mutation
• Female dog
• Weigh over 10 kg
• A life expectancy of at least 2 months
Owner's Responsibilities (Samples and Information to be collected):
• Physical exams performed at each study visit along with clinical tests associated with the trial
• Chest radiographs and ultrasound performed to assess disease burden and progression
• Cystoscopy with tumor biopsy (2)
• Treatment of any side effects associated with the vaccine
All Dogs, Scottish Terriers, West Highland White Terriers, Shetland Sheepdogs, Beagles, and Parson Russell TerriersMore Information
Name: Ali Carroll
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.