Genome-wide association mapping study of hypertrophic osteodystrophy in Irish Setters
The purpose of this work is to identify SNPs that are linked to HOD in the Irish Setter. HOD is a debilitating, metabolic bone disease that, in mild cases, can lead to deformation of mature bone, and in severe cases, can require euthanasia of affected dogs. At present, the etiology of HOD is unknown. The most frequently proposed causes are distemper virus infection, post-vaccination infection, bacterial infection, or other viral infections. All of these include an associated immune-related response. Due to the complex nature of the immune system and its many components, a search for candidate genes would be exhaustive, expensive, and time consuming. The most efficient resource for identifying genomic regions associated with disease is the canine SNP array, which utilizes natural variations among dogs and looks for patterns common among all affected dogs. Such regions can be targeted for further studies with the ultimate goal of identifying the mutation(s) that lead to disease. These mutations may allow for the development of a genetic test. A genetic test predictive for HOD has the potential to (1) improve existing diagnostic procedures, (2) aid in the development of new preventive protocols (e.g., vaccination series) to avoid exposure to precipitating stresses, and (3) ensure that patients receive prompt, appropriate, and effective therapy. Assuming a genetic etiology is defined, determination of affected and carrier individuals can allow tailored breeding programs aimed at reducing the incidence of HOD without major detriment to breed characteristics.More Information
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