Dogs with Immune Mediated Polyarthropathy

03/15/2012
Breed(s): All Dogs
Study Type: Clinical Study
Study Location: University of Wisconsin, Madison

We are beginning a study to evaluate surrogate markers of inflammation in dogs with immune mediated polyarthropathy (IMPA). IMPA is a common cause of fever of unknown origin and typically causes signs of lameness, joint effusion, lethargy, and anorexia. Diagnosis and monitoring this disease requires arthrocentesis and sedation, which can be technically challenging, expensive, and not without risks to the patient. The overall goal of the study is to identify a surrogate marker of inflammation that correlates with clinical and cellular improvement of polyarthropathy. This marker may possibly be used to monitor treatment efficacy and diagnose relapse of IMPA. Dogs will have force plate analysis and wear an accelerometer attached to their collar to assess lameness and mobility.

Our target population is dogs with naturally occurring IMPA who have negative antibody titers for Borrelia, Anaplasma, and Ehrlichia (Idexx 4DX negative). Dogs will undergo the standard baseline workup for IMPA (CBC, biochemistry, urinalysis, joint radiographs and arthrocentesis). Additionally, all dogs will have kinetic force plate analysis performed and be fitted for an accelerometer to be worn on their collar for the duration of the study. This initial work-up will be performed at the VMTH. An additional 6 mls of blood will be used for the study. Dogs will be treated with a standard protocol of Prednisone. Recheck examinations will occur 2 and 4 weeks later at the VMTH, during which repeat arthrocentesis and force plate analysis will be performed and 5 mls of blood will be obtained to quantify markers of inflammation.

The advantage to the client is that their dog will receive initial joint radiographs, and recheck appointments and diagnostics (internist exam, complete blood count, biochemical panel, urinalysis, force plate analysis, arthrocentesis, and synovial fluid analysis) at no cost.

More Information

 

Contact Information:

Please contact Dr. JD Foster (608-263-7600) or Dr. Lauren Trepanier (608-265-9022) with any questions regarding the study.

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