Differences Between Dogs With and Without Osteosarcoma

Breed(s): -All Dogs
Study Type: Blood Sample
Study Location: North Carolina State University

Osteosarcoma, the most common primary bone cancer in dogs, commonly affects large and giant breeds such as the Scottish Deerhound, Irish Wolfhound, Great Dane, Saint Bernard, Greyhound, Rottweiler, Boxer, Golden Retriever, and Labrador Retriever. With more than 8000 cases diagnosed per year in the United States, it is crucial that we constantly strive to improve the outcome of dogs affected by the disease. Unfortunately, survival times have not greatly improved over the last 20 years. Even after surgical tumor removal and chemotherapy, the cancer usually metastasizes and dogs often die of metastatic disease within an average of 12 months after diagnosis, despite aggressive therapy.

Researchers at NCSU made the interesting observation that survival times can double in osteosarcoma patients who develop infections associated with limb-spare surgeries. These infections may be capable of activating the immune system via monocytes (a type of white blood cell), to promote anti-tumor activity, as has been shown in mouse models. Therefore, we need to understand the role of monocytes in canine osteosarcoma in order to harness their anti-tumor capabilities.

The purpose of this study is to characterize phenotypic (surface receptor expression) and functional differences of monocytes between normal dogs, and osteosarcoma dogs either with or without a concurrent infection. We proposed to collect blood samples from normal dogs, osteosarcoma dogs that have not been treated, osteosarcoma dogs that have undergone standard-of-care therapy, and osteosarcoma dogs that have an infection associated with their limb-sparing procedure.

We would greatly appreciate blood samples from dogs with osteosarcoma that have undergone standard-of-care therapy and osteosarcoma dogs that have an infection associated with their limb-sparing procedures. Please contact Joanne Tuohy at joanne_tuohy@ncsu.edu for more details if there are potential samples available.


Contact Information:
Janne Tuohy
Email: joanne_tuohy@ncsu.edu

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