Clinical and Molecular Genetic Analysis of Juvenile-Onset Laryngeal Paralysis in American Staffordshire Terriers
We will attempt to identify the molecular genetic cause of a newly recognized, fatal, neurologic disease referred to as American Staffordshire Terrier juvenile laryngeal paralysis and polyneuropathy (AST-JLPP) by generating and analyzing whole genome sequences with DNA from affected puppies with AST-JLPP. A genome-wide association study will be used to map the AST-JLPP. Successful discovery of the causal mutation would provide a basis for DNA tests that could be used to confirm a diagnosis of AST-JLPP and aid breeders for marker-based breeding strategies.
Affected puppies diagnosed with AST-JLPP
Owner Responsibilities (Samples to be collected):
DNA samples (via whole blood in EDTA, OR, buccal cells on FTA-elute cards)
Pedigree copy (if available)
Name: Dr. Gary Johnson; Liz Hansen (for participation)
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.