Alaskan Malamute Chondrodysplasia

03/14/2014
Breed(s): Alaskan Malamute
Study Type: Blood Sample
Study Location: University of Helsinki and Folkhälsan Research Center

The Alaskan Malamute breed suffers from inherited chondrodysplasia. Affected malamutes have a disturbance in the process of endochondral ossification, which results in short stature and curvature of the front limbs. The disease is thought to be inherited trough a single gene, in an autosomal recessive manner. The molecular genetic background of the disease is yet to be identified. The identification of the causative mutation would enable us to develop a genetic test for breeding purposes, and it would help us to understand how the disease develops in both dogs and in humans. We have been using two complementary research methods to discover the causative mutation: exome sequencing and genome-wide association mapping. Our current results are promising but more samples are needed to confirm these findings. If new chondrodysplasia cases appear, we would be very interested in receiving blood samples from both affected dogs and their healthy relatives. Blood samples are preferred because of DNA quality and yield.

 

Contact Information:
Dr. Hannes Lohi; Kaisa Kyöstilä
Email:Hannes.lohi@helsinki.fi; kaisa.kyostila@helsinki.fi

Phone: +358-9-191-25085, +358-9-191-25678

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