1572: Development of a Novel Therapeutic For Neutrophil-Driven Inflammation
Grant Status: Open
Grant Amount: $63,580
Dr. Samuel L. Jones, DVM, PhD, North Carolina State University
January 1, 2012 - December 31, 2013
Breed(s): -All Dogs
Research Program Area: Lung and Respiratory Disease
Abstract White blood cells called neutrophils are essential for host defense. When activated, they produce an array of proteins and other molecules that kill invading microbes. However, these products also are quite damaging to host tissues. Neutrophil functions are often not regulated properly in acute and chronic inflammatory diseases of the respiratory tract and other body systems; in fact, neutrophils account for much of the damage in many inflammatory diseases. Dr. Ken Adler's laboratory has developed a novel compound called the MANS peptide that inhibits the protein called MARCKS in human neutrophils. Dr. Jones' lab will determine whether the MANS peptide can inhibit canine neutrophil activation and thus have utility in the treatment of serious inflammatory disease in dogs.