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01312: Association mapping study of Legg-Calve-Perthes Disease in the West Highland White Terrier, Yorkshire Terrier, and Cairn Terriers

Grant Status: Open

Grant Amount: $78,688
Dr. Alison Starr-Moss, PhD, Clemson University
January 1, 2010 - June 30, 2013
Sponsor(s): Australian Terrier Club of America, Border Terrier Club of America, Miniature Pinscher Club of America, Inc., Orthopedic Foundation for Animals, Parson Russell Terrier Association of America, Pug Dog Club of America, Inc., Schipperke Club of America Rescue and Health Foundation, The Foundation of the Cairn Terrier Club of America, The K9 College, Versatility in Poodles, Inc., West Highland White Terrier Club of America, Westie Foundation of America, Inc., Yorkshire Terrier Club of America, Yorkshire Terrier Club of America Foundation, Inc.
Breed(s): West Highland White Terrier, Cairn Terrier, Yorkshire Terrier
Disease(s): Legg-Calve-Perthes Disease
Research Program Area: Musculoskeletal Conditions and Disease


Background: Legg-Calve-Perthes Disease (LCPD) is a debilitating developmental disease that affects small breeds of dog, particularly terrier breeds. The only outward indications of this condition are pain, lameness, and muscle atrophy of the hip joint. These signs are not exclusive to LCPD, and are often attributed to minor trauma during the early stages of disease. LCPD is primarily diagnosed by radiographic changes of the femoral head within the hip joint. Due to the developmental nature and the unknown etiology of the disease, LCPD is difficult to predict and prevent. No disease mapping strategies have been employed to date. Objective: This study is using the Affymetrix canine single nucleotide polymorphism (SNP) chip to identify regions that are linked to LCPD in the West Highland White Terrier, Yorkshire Terrier, and Cairn Terrier breeds.


Starr-Moss AN, Nowend KL, Alling KM, Zepp EJ, Murphy KE (2011) Exclusion of COL2A1 in canine Legg-Calv�-Perthes disease. Animal Genetics. doi:10.1111/j.1365-2052.2011.02215.x
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