01311: Genome-wide association mapping study of hypertrophic osteodystrophy in Irish Setters
Grant Status: Open
Grant Amount: $74,237
Dr. Alison Starr-Moss, PhD, Clemson University
January 1, 2010 - June 30, 2013
Sponsor(s): Irish Setter Club of America Foundation, Irish Setter Club of Milwaukee, Inc.
Breed(s): Irish Setter
Research Program Area: Musculoskeletal Conditions and Disease
Abstract Background: Hypertrophic osteodystrophy (HOD) is a debilitating, metabolic bone disease that, in mild cases, can lead to deformation of mature bone, and in severe cases, can require euthanasia of affected dogs. At present, the cause of HOD is unknown. Most cases of HOD are observed shortly after vaccinations, the most often proposed causes are distemper virus infection, post-vaccination infection, bacterial infection, or other viral infections. The predominance of HOD in several breeds of dog suggests a heritable component of the disease. Due to the complex nature of the immune system and its many components, analysis of candidate genes would have to be exhaustive.
Objective: The researchers aim to identify genes involved in HOD with the whole genome association mapping using the canine single nucleotide polymorphism (SNP) chip. This resource will identify regions exhibiting linkage with HOD. Such regions will then be assessed for gene(s) involved in the disease.