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00859-A: Canine Immune-Mediated Hemolytic Anemia

Grant Status: Closed

Grant Amount: $12,960
Dr. Lorna J. Kennedy, PhD, University of Manchester
January 1, 2007 - December 31, 2008
Breed(s): -All Dogs
Research Program Area: Prevention

Project Summary

We have previously identified a set of genes associated with Immune Mediated Haemolytic Anaemia (IMHA) in a region of the genome that is rich in immune genes. We have now performed a whole genome scan comparing 35 Cocker and Springer Spaniels having IMHA with 49 unaffected control dogs, which has revealed 91 SNPs that are significantly associated with IMHA, and are spread over 33 different canine chromosomes. Eight of these SNP associations are highly significant and give us great hope that we will be able to identify other genes/loci associated with this disease. If we can identify such genes, it may be possible to start selective breeding to reduce the risk of Cocker and Springer Spaniels developing IMHA.
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