759: Investigation of Antigenic Causes of Vaccine-Associated Allergic Reactions in Dogs
Grant Status: Closed
Grant Amount: $31,631.12
Dr. George E. Moore, DVM, PhD, Purdue University
January 1, 2007 - December 31, 2008
Sponsor(s): Affenpinscher Club of America, American Belgian Tervuren Club, Inc., American Cavalier King Charles Spaniel Club Charitable Trust, American Sealyham Terrier Club, Bernese Mountain Dog Club of America, Border Terrier Club of America, Boston Terrier Club of America Charitable Trust, Bull Terrier Club of America, Bulldog Club of America Charitable Health Fund, Inc., Chihuahua Club of America, Collie Health Foundation, Dalmatian Club of America Foundation, Inc., French Bulldog Club of America, French Bulldog Rescue League, Greyhound Club of America, Health & Rescue Foundation of the Petit Basset Griffon Vendeen Club of America, Italian Greyhound Club of America, Miniature Pinscher Club of America, Inc., National Amateur Retriever Club, Pug Dog Club of America, Inc., Seminole Kennel Club, Skye Terrier Club of America, Soft Coated Wheaten Terrier Endowment Fund, Tibetan Spaniel Club of America, Tibetan Terrier Club of America/Tibetan Terrier Health & Welfare Foundation, United States Kerry Blue Terrier Club, Inc., Vizsla Club of America Welfare Foundation, Welsh Terrier Club of America, Inc., Westie Foundation of America, Inc., Yorkshire Terrier Club of America Foundation, Inc.
Breed(s): -All Dogs
Project Summary Researchers at Purdue University were funded by the AKC Canine Health Foundation to identify causes of vaccine-induced allergic reactions. Small dogs in general, and several specific breeds, are known to be at higher risk for these reactions. Although the precise cause of allergic reactions in dogs remains unknown, vaccine components residual from the manufacturing process have been incriminated. These vaccine components need to be identified if possible, so that manufacturers can make vaccines safer for dogs.
This study compared antibody concentrations in dogs recently experiencing allergic reactions after vaccination to the antibody concentrations in dogs of the same breed that were vaccinated but didn't have reactions. Comparisons were made by measuring the serum antibody (lgE) reactivity against selected vaccine components. Although samples were solicited from several breeds, only Beagles and Dachshunds provided enough samples for breed-specific comparisons.
Grouped together without regard to breed, there were no significant differences between the 46 allergic reactors' and the 50 non-reactors' antibody responses to any of the 7 assayed antigens. When evaluated by breed, however, Beagles demonstrating allergic reactions immediately after vaccination had greater serum response to two vaccine components (fibr.onectin and thyroglobUlin) compared to the responses of vaccinated asymptomatic littermates. Dachshunds with reactions did not have greater serum response to any of the measured vaccine components, and in two assays the serum response of nonreactors was actually greater than for reactors. As voluntary submissions, however, the Dachshunds in these two groups were not related nor did they receive the same vaccines.
The results of this study indicate that different vaccine components can stimulate antibody response immediately after vaccination, but not all dogs with high response show clinical signs of an allergic reaction. This suggests that dogs with post-vaccinal allergic reactions may have a genetic predisposition which affects the release of chemical mediators from mast cells, and there may not be a vaccine component common to all or most allergic reactions.
Further information related to the study will be posted at: http://www.vet.purdue.edu/k9vaxrxn/.
Publication(s)- Moore, G.E., HogenEsch, H., 2010, Adverse Vaccinal Events in Dogs and Cats. Veterinary Clinics of North America: Small Animal Practice 40, 393-407.