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00372: Determination of Breed-Specific Reference Ranges for Assessing Thyroid Function in Several Breeds

Grant Status: Closed

Grant Amount: $91,350

Dr. Rebecca L. Davies, PhD, University of Minnesota

July 1, 2005 - June 30, 2010

Sponsor(s): Alaskan Malamute Research Foundation, Inc., English Setter Association of America, Inc., Golden Retriever Foundation, Keeshond Club of America, Orthopedic Foundation for Animals, Samoyed Club of America Education & Research Foundation, Siberian Husky Club of America Trust

Breed(s): Alaskan Malamute, English Setter, Golden Retriever, Keeshond, Samoyed, Siberian Husky

Disease(s): Hypothyroidism

Project Summary

All dogs have completed the recruitment, enrollment and screening process. All samples from all dogs have been collected. Six hundred dogs were enrolled and 77 dogs were rejected due to their failure to pass inclusion criteria. All analytical testing (health screening data and hormone analyses) has been completed. Preliminary data has been presented at the American College of Veterinary Internal Medicine meeting in Anaheim, Ca in June 2010 where it was concluded that Basal serum T4 and FT4D concentration vary among breeds and use of breed-specific reference intervals is recommended when evaluating thyroid function in purebred dogs. Final manuscript preparation is underway to be submitted in early 2011. The research team greatly appreciates the support of AKC, the CHF, the OFA and the AKC dog clubs and officers. Thank you for giving us this opportunity to carry out this work. We look forward to communicating the results of this study soon.

Publication(s)

Sharkey, L., K. Gjevre, R. Hegstad-Davies, S. Torres and C. Mu�oz-Zanzi (2009) Breed-associated variability in serum biochemical analytes in four large-breed dogs. Veterinary Clinical Pathology. 38, 375-380. Manuscript in preparation "Breed- Spedific Reference Intervals for Assessing Thyroid Funcation in Seven Dog Breeds."