0001836: Identifying the Genetic Cause of Canine Hip Dysplasia
Grant Status: Closed
Grant Amount: $165,000
Dr. George J. Brewer, MD, University of Michigan
July 29, 1999 - July 28, 2002
Sponsor(s): Alaskan Malamute Club of America, Inc., Great Dane Club of America, Orthopedic Foundation for Animals, Rottweiler Health Foundation, Samoyed Club of America Education & Research Foundation
Breed(s): -All Dogs
Project Summary Canine Hip Dysplasia is the number one genetic health problem in dogs, with a significant frequency in over 100 breeds. The mode of inheritance may be polygenic (due to more than one gene) which adds to the complexity of identifying the genetic cause. This research project evaluated 12 candidate genes across 11 breeds to try to identify variance within a candidate gene contributes to the inheritance of hip dysplasia. The research ruled out all 12 candidate genes as associated. Further genome-wide linkage analysis across 24 dogs in 3 breeds also did not identify genetic associations for hip dysplasia.