Progressive Retinal Atrophy (PRA) in the English Springer Spaniel RFP

AKC Canine Health Foundation
2018 Progressive Retinal Atrophy (PRA) in the English Springer Spaniel
Request for Research Proposals

The AKC Canine Health Foundation continues its commitment to canine health by seeking critical research proposals to address progressive retinal atrophy (PRA) in the English Springer Spaniel. PRA is a recessive disease in the English Springer Spaniel with late onset signs that lead to blindness in the affected population.

CHF is seeking innovative approaches to characterize PRA in the English Springer Spaniel. Prior research findings of canine PRA identified a recessive mutation in the RPGRIP1 gene in 44 base pair insertions in the Miniature Long-Haired Dachshund. This resulted in a genetic test that later found the same mutation at a high frequency in the English Springer Spaniel population. 

Of special interest are applications proposing inheritance, diagnostic and genetic characterization to improve breeding decisions and quality of life in the English Springer Spaniel by addressing the following:

1.    Focus on understanding the inheritance of Cord 1 PRA in the breed and its relationship to identified recessive mutation
       RPGRIP1 to inform appropriate breed health strategies
2.    Develop diagnostic strategies for “at risk” English Springer Spaniel genotypes that will develop loss of sight
3.    Explore other genes in the English Springer Spaniel not found in the Miniature Long-Haired Dachshund that may
       interact with RPGRIP1 gene to possibly modify Cord 1 cone rod dystrophy; and explore the MAP9 mutation found in the
       Miniature Long-Haired Dachshund as it may apply to the English Springer Spaniel

The deadline for online applications is Monday September 17th, 2018 at 11:59 PM Eastern. Both Acorn ($15,000 maximum including 8% maximum indirect costs) and Oak (over $15,000 - $100,000, including 8% maximum indirect costs) grant proposals that can be completed within the budget will be accepted for review.

All work completed under this funding must strictly adhere to the Foundation's Humane Use of Animals Policy.

Questions regarding this RFP should be directed to Andrea Fiumefreddo, CHF Director of Programs.

Please forward this announcement to other researchers seeking funding in this area of research.

Acorn Application

Oak Application

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