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The AKC Canine Health Foundation has strongly supported cancer research since its inception in 1995. Cancer medicine has evolved significantly during this time into a more molecularly-based discipline with improved diagnosis and tumor imaging, and the discovery of novel therapeutics aimed at cancer-specific cellular signal transduction pathways. In continuation of our strong support of canine cancer research, the Oncology Research Program remains committed to the promotion of innovative research that will aid in the discovery of advanced diagnostic technology and therapeutic target identification.
Thanks to CHF-funded research, we now know that the alterations underlying specific cancer types need to be interpreted within the context of 1) the complex networks of interactions that occur within the cell and 2) the genetic background of the individual dog and/or breed. It is widely appreciated that our funded molecular research has significantly contributed to improved prognostic and diagnostic tools, as well as improved responsiveness to existing therapies, and, most importantly, identification of new therapeutic targets. In light of our success, the Oncology Research Program will continue to support research aimed at strengthening our understanding of the molecular and genetic basis of disease.
There is new evidence that we must deepen our understanding of the heterogeneous nature of tumors in order to make progress in the battle against canine cancer. Included in tumor heterogeneity is the presence of cancer stem cells which are thought to support tumor progression, metastasis and impair susceptibility to chemotherapeutic intervention. In order to make sense of the complexity of cancer, new approaches are needed to provide comprehensive characterization of tumors. These approaches will likely require broad bioinformatic analyses, high throughput methodologies and systems biology tools. As with all other research program areas, collaborative, multi-disciplinary teams of investigators who can approach discovery research from a multi-‘omics’ perspective will be considered more competitive than a genomic approach working in isolation. Beyond the molecular and genetic basis of disease, the Oncology Research Program area will continue to support the identification and evaluation of potential therapeutics to treat canine cancer.
Special topics of interest within the Oncology Research Program include, but are not limited to:
Please read an open letter to applicants concerning changes to our grant process from previous cycles.
Learn about research funding opportunites and submission procedures.
You can make contributions to support the specific areas of research that match your interests or greatest health concern.
Your help is needed with canine health research. DNA and tissue samples are needed from healthy dogs and dogs affected by certain diseases.