Musculoskeletal Conditions and Disease Research Program RFP
Due Date: July 7, 2015
The AKC Canine Health Foundation’s Musculoskeletal Conditions and Disease Research Program supports research aimed at improving the diagnosis, treatment, and prevention of diseases and injuries of the musculoskeletal system and its component tissues.
Grants are requested for the following topic:
- Legg-Calve-Perthes disease
Legg-Calve-Perthes Disease (LCPD) is a developmental disease characterized by osteonecrosis of the coxofemoral joint in young dogs less than 18 months of age. LCPD most frequently occurs in small breeds and the etiology is currently unknown. Human LCPD has been associated with COL2A1; however, a recent study ruled out COL2A1 as a candidate gene responsible for canine LCPD. Recent imaging of dogs with LCPD observed an increase in trabecular count and a smaller trabecular thickness, altering the predominant hypothesis that disease was the result of thickening of the bone trabeculae caused by layering of new bone matrix on top of necrotic trabeculae. Based on these recent studies, CHF seeks to fund a transcriptomics/proteomics pilot project that will provide preliminary data regarding the mechanism of accelerated trabecular regeneration that leads to disease pathogenesis.
Funding limit $12,000 + 8% indirects. Both pilot projects and full projects that can be completed within the budget will be accepted.
Please read an open letter to applicants concerning changes to our grant process from previous cycles.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.