Musculoskeletal Conditions and Disease Research Program RFP

Due Date: July 7, 2015

The AKC Canine Health Foundation’s Musculoskeletal Conditions and Disease Research Program supports research aimed at improving the diagnosis, treatment, and prevention of diseases and injuries of the musculoskeletal system and its component tissues.

Grants are requested for the following topic:

  • Legg-Calve-Perthes disease

Legg-Calve-Perthes Disease (LCPD) is a developmental disease characterized by osteonecrosis of the coxofemoral joint in young dogs less than 18 months of age. LCPD most frequently occurs in small breeds and the etiology is currently unknown. Human LCPD has been associated with COL2A1; however, a recent study ruled out COL2A1 as a candidate gene responsible for canine LCPD. Recent imaging of dogs with LCPD observed an increase in trabecular count and a smaller trabecular thickness, altering the predominant hypothesis that disease was the result of thickening of the bone trabeculae caused by layering of new bone matrix on top of necrotic trabeculae. Based on these recent studies, CHF seeks to fund a transcriptomics/proteomics pilot project that will provide preliminary data regarding the mechanism of accelerated trabecular regeneration that leads to disease pathogenesis.

Funding limit $12,000 + 8% indirects. Both pilot projects and full projects that can be completed within the budget will be accepted.

Please read an open letter to applicants concerning changes to our grant process from previous cycles.

View instructions to apply for ACORN Grant (≤ $12,000) funding >>

Apply for an ACORN Grant (≤ $12,000) in the Musculoskeletal Conditions and Disease Research Program Area >>

View recently funded research in the Musculoskeletal Conditions and Disease Research Program Area >>

Return to main RFP page >>

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