Cardiology Research Program RFP
The Cardiology Research Program is designed to support integrated basic and clinical research to study normal and abnormal cardiovascular development. This program supports research in the general areas of:
Heart Development: normal and abnormal cardiovascular development, molecular and genetic etiology of cardiovascular malformations, and gene-environment interactions in development of congenital heart disease.
Structural Disease: congenital heart disease from birth through adulthood, valve disease and determinants of degeneration, myocardial response to valvular disease, neurodevelopmental associations with heart disease, exercise physiology in heart disease, dilated and hypertrophic cardiomyopathy.
Arrhythmias: arrhythmogenesis, genetic and environmental bases of normal cardiac electrical activity and arrhythmias, etiology of rare and common arrhythmias, and sudden cardiac death.
Diagnostics: proteomic, genomic, and other biomarker technologies that define disease progression and prognosis. Imaging modalities/agents to identify cardiovascular disease and guide therapy.
Therapeutics: tissue, cell, and gene-based/guided therapies, regenerative and reparative medicine.
Surgery: improved surgical and image-guided approaches and evidence-based clinical research to advance promising new cardiovascular therapies, technologies, and surgical practices into clinical use.
Enabling Technologies in research discovery, including bioinformatics, computational and systems biology, bioengineering, nanotechnology, materials research, and personalized medicine.
Topics of special interest include, but are not limited to:
- Mitral Valve Disease
- Dilated Cardiomyopathy
- Subvalvular Aortic Stenosis
- Congestive Heart Failure
- Patent Ductus Arteriosus
- Aortic Stenosis
- Tricuspid Valve Dysplasia
- Pulmonary Stenosis
- Atrial Fibrillation
- Ventricular Arrhythmias
- Pulmonary Hypertension
Longitudinal studies for Mitral Valve Disease and Cardiomyopathy that integrate early diagnosis (novel biomarker identification) and treatment with evaluation of progression of disease are of priority. Studies defining mechanism of disease are of similar priority. Finally, basic science regenerative medicine studies that identify novel, cell-free factors that are restorative of damaged heart tissue are of strong interest.
The AKC Canine Health Foundation is not currently accepting grant applications in this research program area.
Please read an open letter to applicants concerning changes to our grant process from previous cycles.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.