2020 Dental Disease Request for Proposals

AKC Canine Health Foundation

2020 Dental Disease Request for Proposals (RFP)

Periodontal disease is a condition in which the tissue around the tooth root becomes swollen and infected. This condition can cause tooth loss and systemic illness if not treated. It is highly likely that predisposition to periodontal disease depends on one or more of the following: (1) the oral flora; (2) the immune system of the individual dog; (3) genetic makeup and/or regulation of gene expression; (4) nutrition and nutritional status. Periodontal disease can be extremely painful and decrease a dog’s quality of life. The AKC Canine Health Foundation is committed to understanding factors that influence the development of periodontal disease and dental disease, in general, and ultimately providing veterinarians and dog owners with the resources necessary for better canine dental health. Topics of special interest include, but are not limited to:

  • Identification of patients at low risk and high risk of periodontal disease through identification of biological markers of disease, including both genomic/transcriptomic markers of risk, unique attributes of the oral microbiome, and clinical intraoral characteristics.
  • Identification of specific bacterial antigens that may have utility in a preventative periodontal disease vaccine
  • Characterization of the immune response in the oral cavity of patients at low risk and high risk for the disease
  • Characterization of the microbiome in the oral cavity of patients at low risk and high risk for the disease
  • Characterization of highly conserved bacterial antigens that could be used for subsequent periodontal disease vaccine development
  • Evaluation of the role of comorbidities, such as obesity and diabetes, in exacerbation of periodontal disease
  • Nutritional approaches to better oral health

The deadline for online applications is Wednesday, March 18th, 2020 at 11:59 PM Eastern. Both Acorn ($15,000 maximum including 8% maximum indirect costs) and Oak (>$15,000 - $100,000 including 8% maximum indirect costs) grant proposals that can be completed within the budget will be accepted for review.

All work completed under this funding must strictly adhere to the Foundation's Humane Use of Animals Policy.  Funding eligibility details can be found here.

Questions regarding this RFP should be directed to Andrea Fiumefreddo, CHF Director of Programs & Operations.

Please forward this announcement to other researchers seeking funding in this area of research.

Acorn Application
Oak Application
Access Saved Applications

Previously awarded CHF grants and active research in this area can be found here: Periodontal Disease

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